The sixth stage is the first true climb-focused stage that the climbers will have circled on their calendars. The race begins in Remiremont, a small town in the French department of Vosges. The first hundred kilometers feature continuous ups and downs, though it's not overly demanding at this point. The Col du Mont de Fourche (3.2 km at 5.9%) and the Col du Ferrière (2.6 km at 4.7%) are the two categorized climbs early in the stage.

Shortly after, the Côte de Laviron (5.7 km at 4.1%) appears, but it comes too early to expect major action. The real contest is likely to begin in the final thirty kilometers. The finale starts with the climb of Roche du Prêtre (5.5 km at 5.6%). The summit of this climb is 26 kilometers from the finish, but the ascent doesn’t end there.

Soon after, the Côte des Fins (1.8 km at 6.9%) presents itself. Following this short but intense climb, the route descends towards the finish in Morteau. Stage six could very well turn out to be a genuine transition stage, despite the cumulative climbs on the previous day adding up to more than 2,200 meters of elevation gain. Therefore, it is certainly not an easy transition stage.